Top 8 Biologics Manufacturing in North Carolina 2026
Last updated
FirmsLedger lists 8 biologics manufacturing companies headquartered in North Carolina. The largest clusters are in Durham (3), Holly Springs (2) and Sanford (2), plus 1 in Clayton. Durham listings include KBI Biopharma - Durham, Merck - Durham and Biogen - Research Triangle Park.
By specialty, North Carolina has sterile injectables & fill-finish (8), oral solid dose (4), API manufacturing (3), vaccine manufacturing (3) and semi-solids & liquids (2) listings. Capabilities that more than one of them list include drug substance (4), biologics CDMO (2), gene therapy manufacturing (2) and mammalian cell culture (2).
| Company | City | Specialty | Phone | Website |
|---|---|---|---|---|
| KBI Biopharma - Durham | Durham | Mammalian cell line development | (919) 479-9898 | kbibiopharma.com |
| FUJIFILM Biotechnologies - Holly Springs | Holly Springs | Biologics CDMO | — | fujifilmbiotechnologies.fujifilm.com |
| Grifols - Clayton | Clayton | Plasma Fractionation | — | grifols.com |
| Merck - Durham | Durham | Vaccine Manufacturing | — | merck.com |
| Amgen - Holly Springs | Holly Springs | Biologics Drug Substance | — | amgen.com |
| Astellas Gene Therapies - Sanford | Sanford | Gene Therapy Manufacturing | — | astellas.com |
| Biogen - Research Triangle Park | Durham | Biologics Manufacturing | — | biogen.com |
| Pfizer - Sanford | Sanford | Gene Therapy Manufacturing | — | pfizer.com |
KBI Biopharma - Durham
Durham, North Carolina
KBI Biopharma operates a contract development and manufacturing organization (CDMO) focused on biologics from its Durham, North Carolina facility The company is a subsidiary of JSR Life Sciences and maintains additional sites in Research Triangle Park, Boulder, Louisville, The Woodlands, Geneva, and Leuven. While the firm celebrates 30 years of experience, an explicit founding year is not disclosed.
FUJIFILM Biotechnologies - Holly Springs
Holly Springs, North Carolina
FUJIFILM Biotechnologies operates a large-scale contract development and manufacturing organization (CDMO) site in Holly Springs, North Carolina. The facility is part of Fujifilm Corporation's global biologics network, which maintains additional production sites in the United States and Europe.
Merck - Durham
Durham, North Carolina
Merck’s Durham, North Carolina site houses a 225,000-square-foot facility dedicated to vaccine manufacturing. The site operates as part of Merck & Co., Inc., a global biopharmaceutical company headquartered in Rahway, New Jersey, with a history spanning more than 130 years of developing medicines and vaccines.
Frequently asked questions
Which biologics manufacturing companies in North Carolina list drug substance?
4 companies list it: FUJIFILM Biotechnologies - Holly Springs, Merck - Durham, Astellas Gene Therapies - Sanford and Biogen - Research Triangle Park.
Which certifications do biologics manufacturing companies in North Carolina list?
cGMP: KBI Biopharma - Durham and FUJIFILM Biotechnologies - Holly Springs.